(PhD) 9/1991-8/1995 Johns Hopkins University, Department of Environmental Health Sciences
Massachusetts Institute of Technology, Department of Biology Post-doctoral Associate, 9/1995-1/2000
Massachusetts Institute of Technology, Department of Biology Research Scientist, 2/2000-4/2003
Chung-Ang University, School of Medicine Assistant Professor, 3/2002-2/2006
TEGO Sciences External director
Korean Nucleic Acids Society Director
관심분야 Research Interest
The main research theme in my laboratory is synthetic biology, which is an emerging field that covers wide range of areas, from the classical protein engineering to metabolic engineering. Since my Ph.D study, I have been interested in nucleic acid binding proteins as well as nucleic acids. Most works have focused on developing new tools to control gene expression and designing new proteins with novel functions. Currently research topics in my lab can be classified as follows:
Protein and Nucleic acid chemistry: Structural and functional study of protein-nucleic acid interaction.
Bioengineering: Developing tools for molecular biology and gene therapy.
Nanobio-Chemisty: Assembling nanostructures using biomaterials and inorganic materials.
연구키워드 Research Keyword
Nucleic Acid, Protein Engineering, Synthetic Biology, Genome modifying nuclease, Z-DNA
연구성과 Major Research Achievements
Cytoprotective Alginate/Polydopamine Core/Shell Microcapsules in Microbial Encapsulation.
Angew Chem Int Ed, 53(52), 14443-6 (2014)
Recombinant Tagging System Using Ribosomal Frameshifting to Monitor Protein Expression.
Biotechnol Bioeng, 110(3), 898-904 (2013)
Intrinsic Z-DNA is stabilized by the conformational selection mechanism of Z-DNA-binding proteins.
J Am Chem Soc, 133(4), 668-71 (2011)
The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA.
Proc Natl Acad Sci USA, 105(52), 20671-6 (2008)
Proton-fueled, reversible assembly of gold nanoparticles by controlled triplex formation.
Angew Chem Int Ed, 45(36), 5960-3 (2006)
Crystal Structure of a junction between B-DNA and Z-DNA reveals two extruded bases.
Nature, 437(7062), 1183-6 (2005)
A role for Z-DNA binding in vaccinia virus pathogenesis.
Proc Natl Acad Sci USA, 100(12), 6974-9 (2003)
Hybrid restriction enzymes: Zinc finger fusions to FokI cleavage domain.