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교수소개 - 생명과학과

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  • 교수 바이러스학
  • 배용수 홈페이지 바로가기

[관심분야]

I am interested in following three research fields: 1) As a first project, we have been focusing on the molecular differentiation of DC subsets from bone marrow progenitor cells and their immunogenicity and immune regulation. 2) Second project is the study on the role and functions of p53 and PKR under stress conditions, such as HIV-1 infection, genotoxic stresses, inflammatory stresses etc. 3) Third project is a development of mucosal CTL vaccines using poliovirus vector system.

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  • 교수 세포학
  • 이석희

[관심분야]

Male Reproduction

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  • 교수 면역학
  • 이충은

[관심분야]

The current research focus is on the modulators of cytokine signaling (SOCS) action to control inflammation and tumor progression using in vitro and in vivo model systems

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  • 교수 식물생리학
  • 이우성
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  • 교수 동물생리학
  • 박영민

[관심분야]

A Role of Annexins and Phospholipase A2 in the Regulation of Insulin SecretionAnnexins are a superfamily of proteins that are expressed in the majority of mammalian cells as well as molds and plants. A notable characteristic of all the members is that they bind to phospholipids in a Ca2+-dependent manner. Various annexins play a regulatory role in the exocytosis of secretory vesicles in adrenal chromaffin cells, anterior pituitary cells, and pancreatic ß-cells. In these cells, intracellulaf annexins play a role in the regulation of exocysis of secretory vesicles. However, the regulatory mechanisms of intracellular annexin I on the secretory machinery have yet to be fully explained.The phopholipase A2 (PLA2, phosphatide 2-acylhydrolase, EC 3.1.1.4) is a superfamily of distinct enzymes that catalyze specifically the hydrolysis of the sn-2 eter bond of phospholipids to yield free fatty acids and lysophospholipids. PLA2 enzymes have been implicated to play a role in various cellular processes and responses such as phospholipid digestion and metabolism, membrane remoldelling, host defense, differentiation, mitogenesis, exocytosis, and cytotoxicity.We currently investigate the regulatory mechanisms of annexins and phospholipase A2 on the insulin secretion in pancreatic islets and insulimona cells to gain an insight into its mode of action.

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  • 교수 분자당생물학
  • 김철호 홈페이지 바로가기

[관심분야]

Research interests are on glycomics and glycobiology, expecially on sphingolipid, ceramide and sialic acid-containing sphingolipids, ganglioside. Academic findings: Hepatic B Viral hepatocarcinoma and PTEN (Cancer Res 2003), asialo-1 acid glycoprotein in liver cirrhosis and carcinoma (Hepatol Res, 2003), GlcNAc:βMan1,4GlcNAcT-III in hepatitis (Glycoconj J, 2003), plasma MMP-9/2 and α-fetoproteins in HBV chronic hepatitis (J. Gastroent Hepatol 2004), HBV metastatic potential (FASEB J. 2004), Hepatic V and GnT-III-Apolipoprotein B (JBC. 2004), Disialo GD3 in VSMC responses (JBC. 2004), therapeutic hepatocarcinoma cells (FASEB J. 2004), Transglutaminase 2 signaling in leukemia (FEBS Lett. 2004), bisecting N-GlcNAcT-III in HBV (J Gastroent Hepatol, 2004), Monosialyl GM3 in leukemic differentiation (Glycobiology 2005), MMP-9 in In Vitro Fertilization (British J Obstetrics and Gynecology 2005), disialo GD3 Fas-induced T cells (Glycobiology 2006), GM3 in PTEN-mediated progression (Glycobiology 2006), ROS in sialic GD3-cell function (FASEB J 2006), AP-2a in GM3-PTEN (Glycobiology 2008), sialidase in leukemia (Biochim Biophys Acta 2008), GM3-VEGFR-2 interaction (Glycobiology 2009), GD3 in breast cancer cells (Biological Chemistry 2009), pig CMAH and N-glycolylneuraminic acid (Biochem J 2010), pST6GalNAc IV for Neu5Aca2-3Galb1-3GalNAc (Glycoconj J 2011), GM3 in TGF-β1-induced EMT (Biochem J. 2013), VEGFR-2 in neovascularization (J Mol Medicine 2013), monosialyl GMs (Plos One 2014) and TGF-receptor interaction (Int. J. of Biochem. Cell Biol. 2014), Sialyl Le A/X preference of HBx (Mol Cancer 2014, J Cell Biochem 2015).

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  • 교수 분자환경생물학
  • 이재성 홈페이지 바로가기

[관심분야]

oxidative stress, DNA repair, marine genomics, ecotoxicology, whole genome

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  • 교수 해양저서 군집생태학
  • 김정하 홈페이지 바로가기

[관심분야]

Marine Ecology Laboratory of Sungkyunkwan University carries out a variety of research projects concerning Korean marine environments, which include 1) ecological monitoring of marine benthic habitats with regard to global warming and seawater temperature changes, 2) population ecological works of introduced species and endangered species for their conservation perspectives, 3) molecular ecological works on populations of seaweeds and marine invertebrates, 4) urchin barrens (백화현상) and recovery of kelp forest. Most of these projects have been conducted with international and domestic research co-work teams. Researches in my lab covers from field experimental works to molecular ecological works.

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  • 교수 식물분류학
  • 김승철 홈페이지 바로가기

[관심분야]

I am primarily interested in systematics and evolutionary biology of plants. In particular, I am interested in the origin and evolution of plant endemics on oceanic islands, including the Macaronesian Islands in the Atlantic Ocean and Jeju and Ulleung Island in Korea. I am also interested in revealing complex evolutionary history of polyploidy and homoploidy lineages of flowering plants. Additional research interests include conservation genetics of rare and endangered species, population genetics of invasive weedy species, ethnobotany, plant domestication, and phylogeography of east Asian plants. A variety of techniques and molecular markers are utilized to unravel the phylogenetic patterns and underlying processes generating plant diversity.

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  • 교수 분자유전학
  • 최철용 홈페이지 바로가기

[관심분야]

Phosphorylation and ubiquitination are reversible post-translational modifications with key roles in various signal transduction cascades. Currently, cancer cell-specific metabolic adaptation is a hot issue to be addressed. The mammalian target of rapamycin (mTOR) signaling pathway integrates both intracellular and extracellular signals and serves as a central regulator of cell metabolism, growth, proliferation and survival. The mTOR pathway is activated during various cellular processes such as tumor formation and angiogenesis, insulin resistance, adipogenesis and is deregulated in human diseases such as cancer and diabetes. Although ubiquitination of target protein plays a critical role in other cellular activity during tumorigenesis, little is known about functional relevance of ubiquitin-mediated coordination of mTOR pathway and autophagy induction. So we have interested in the deciphering molecular networks of signaling pathway particularly associated with human diseases caused by malfunction of nutrient sensing.

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  • 교수 분자세포생물학
  • 박석희 홈페이지 바로가기

[관심분야]

TGF-beta is a pivotal cytokine which is involved in a variety of cellular functions. Our group has been focused on the signaling pathways mediated by TGF-beta superfamily cytokines regarding cancer progression and anti-inflammation during the past decade. Our current research focuses on the identification of novel mechanism of TGF-beta or BMP-mediated tumorigenesis and metastasis. In addition, we are also doing the studies about how specific signaling pathways in the inflammation and cancer biology are regulated by ubiquitination and deubiquitinating mechanism. Through these diverse approaches, the final goal in our group is to understand the molecular mechanisms regarding cancer and inflammation and subsequently to identify therapeutic target proteins to treat cancer and inflammation.

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  • 교수 구조생물학
  • 이상호 홈페이지 바로가기

[관심분야]

Life is controlled by a milieu of macromolecular interactions. We focus on understanding structural basis for protein interactions and their applications using a variety of biophysical and biochemical techniques such as crystallography and solution scattering as well as standard techniques in molecular cell biology. We study proteins interactions in ubiquitin signaling, host-pathogen relationship and abiotic stress response signaling. We also develop mini-antibody based bionano sensors for both diagnostic and therapeutic purposes.

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  • 교수 감염 및 염증질환
  • 배외식

[관심분야]

We are interested in the development of bioactive molecules that can be used to treat infectious or inflammatory diseases. Our major target diseases include polymicrobial sepsis, rheumatoid arthritis, inflammatory bowel disease, and colon cancer. To generate useful target molecules that can be used to develop therapeutic agents against these infectious or inflammatory diseases, we are focusing on several chemoattractant G-protein coupled receptors (GPCRs). Since leukocyte trafficking in vivo is a crucial event that modulate immune and inflammatory responses, and chemotactic GPCRs mediate these response, the receptors can be considered as important primary targets to control infectious or inflammatory disorders. Currently, we are testing the effects and mechanism of action of chemotactic GPCR ligands against these diseases in experimental animal models.

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  • 교수 신경유전학
  • 권재영 홈페이지 바로가기

[관심분야]

All animals are born with a set of instincts, or innate behaviors, and our main questions are how complex behaviors are organized in the nervous system and how they are programmed during development. For this, the chemosensory system would be one of the most excellent models. Smell and taste are known to be important for sensing predators, selecting mates as well as finding food. We would like to trace the neuronal pathways that mediate a complex instinctive behavior such as feeding, from sensory input through to motor output. We are using the fruit fly as a model system to study chemosensation.

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  • 부교수 분자진화학
  • 윤환수

[관심분야]

Hwan Su Yoon is an Associate Professor in the Department of Biological Sciences at Sungkyunkwan University, Korea. He received his PhD in biology from Chungnam National University. After research training at the University of Iowa, he worked at the Bigelow Laboratory for Ocean Sciences. His research interests include eukaryotic biodiversity, phylogeny, single cell genomics, and genome evolution, with a focus on red algae and red algal plastid descendants (e.g., the cryptophytes, haptophytes, stramenopiles, and dinoflagellates).

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  • 부교수 세포생물학(피부과학)
  • 이종성 홈페이지 바로가기

[관심분야]

Skin physiology & Signal transduction, Skin diseases & Immunology, Development of functional agents for abnormal skin conditions,

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  • 031-299-4498
  • 제2과학관32동 2층 32208호실