Chronic myelogenous leukemia, the acute phase of the secret is solved
- 자연과학대학
- Hit3199
- 2017-03-15
Our researchers first found the gene involved in the progression of chronic myelogenous leukemia in acute phase.
Professor Kim Hong-tae, a professor at Sungkyunkwan University's Brain Science Imaging Research Center, has succeeded in finding genes involved in the progression of chronic myelogenous leukemia to the acute stage through collaborative research with Professor Kim Dong-wook of Catholic University and Professor Myung Kyung-Jae of UNIST.
The researchers looked for the Coble 1 gene through the next generation gene analysis method, a new precise medical technique, and suggested a clue to overcome the tyrosine kinase inhibitor, a target cancer drug for chronic myelogenous leukemia.
Chronic myelogenous leukemia is a disease caused by "Philadelphia chromosome abnormality", which is caused by excessive proliferation of abnormal cells in bone marrow. In the early stage of the diagnosis, if the mild condition of the chronic phase lasts for 5 ~ 6 years and the target cancer treatment fails, suddenly the leukemic cancer cells grow infinitely and become acute period that leads to death within one year.
In the meantime, researchers around the world have sought to identify the cause of the progression of chronic myelogenous leukemia, but failed to find a definitive gene.
In the next generation of gene analysis methods, which are the latest precise medical techniques, the researchers found that when the Coble 1 gene increases, the symptoms suddenly deteriorate due to tolerance to the target anticancer drugs such as Gleevec, Tac Signa and Sprycel.
Patients with elevated Coble 1 gene expression after acute phase transplantation have also reported that leukemia cells are more likely to respond to targeted chemotherapy if the mortality rate increases and artificially lowered expression of this gene despite treatment with the latest targeted chemotherapy.
Professor Kim Hong-tae, who led the study, said, "Another puzzle about the acute phase progression of chronic myelogenous leukemia resistant to the anticancer drug has been solved by the identification of the Coble 1 gene function." Coble 1 gene is an index that measures progression and prognosis of leukemia. At the same time, it could become a target with the possibility of developing a therapeutic agent that inhibits it. "
The results of the study were published on February 24th in the Internet edition of Leukemia (IF 12.104), the world's leading international journal in the field of sisterhood medicine and blood cancer.