Professor of Chemistry and Professor Song Choongeui, using artificial enzymes to convert toxic substances into high-valu
- 자연과학대학
- Hit3372
- 2017-05-08
Sungkyunkwan University said that the team of Professor Song Choong-ui of the Department of Chemistry has developed a new biomimetic catalyst system with the motif of the metabolism process in vivo.
Among various metabolic reactions occurring in the human body, various glyoxal (alpha-oxoaldehyde) compounds, such as methylglyoxal, which is highly cytotoxic, are converted into lactic acid which is harmless to the human body by detoxification of Glyoxalase I and II enzymes.
The team of Sungkyunkwan University School of Medicine and Professor Song Choongeui focused on the asymmetric isomerization of hemicythioacetal (produced by glyoxal and glutathione) catalyzed by Glyoxalase I enzyme, and hinted at the toxic glyoxal compound. They developed a novel biomimetic organic catalyst system capable of producing chiral α-hydroxythioester compounds with high yield and high optical selectivity, which are considered to be key materials for the synthesis of pharmaceuticals and natural.
Professor Song successfully used chiral α-hydroxythioesters and α-hydroxyamides, which have a variety of medicinal activities, such as chiral drugs, chiral drugs, thereby demonstrated the commercial utility of the new artificial enzyme system.
"It is a biomimetic technology mimicking the natural detoxification enzyme reaction and has originality of research in that it has not only been used as a core raw material for pharmaceuticals but also has developed a new technology capable of synthesizing chiral compounds having various pharmaceutical activities. "This is the first biomimetic catalytic reaction available for industrial applications and is expected to provide a new paradigm for future academic and industry research." In particular, Professor Song said, "The activity of glyoxal degrading enzymes is reduced by aging and various oxidative stresses, which causes accumulation of toxic glyoxal in the body, resulting in various diseases. Therefore, he said that the development of artificial glyoxal degrading enzyme will provide a new starting point for research.
Professor Song Choongeui's team is announcing the groundbreaking results of related organic catalysts in Science and Nature Communications almost every year (2012, 2013, 2015).
“Biomimetic Catalytic Transformation of Toxic α-Oxoaldehydes to High-Value Chiral α-Hydroxythioesters using Artificial Glyoxalase I” (1st author Park, Sangyeon, 2nd author, Hwang Insoo, 3rd author, Lee Hyeonjoo, Contact author Song Choongeui)