Identification of new metastasis of intractable triple breast cancer
- 자연과학대학
- Hit2974
- 2017-10-24
Sungkyunkwan University Professor Park Seok-Hee Research Team (joint research) identified the mechanism of metastasis of metastatic breast cancer including triple-negative breast cancer, collaborating with the Advanced Institutes of Convergence Technology and Gangnam Severance Hospital. It was posted on Nature Cell Biology (IF: 20.06), published online September 11.
It is the first time in the world to identify that the A20 protein, which regulates inflammation and immunity, mediates the metastasis of triple negative breast cancer by inducing multiple mono ubiquitination of Snail1 transcription factors associated with cancer cell migration and invasion.
This study revealed that A20 protein specifically binds to Snail1 protein and mono ubiquitination of three lysine amino acids of Snail1 protein. This mono-ubiquitination of Snail1 induces a decrease in mutual binding to GSK3β, which phosphorylates Snail1 protein, which ultimately proved to be able to induce metastasis by increasing the stability of Snail1 protein in the nucleus. In addition, triple negative breast cancer cell lines inhibited the expression of A20, suggesting that cancer cell resistance to doxorubicin and docetaxel, which are common breast cancer treatments, is reduced.
“As this study provides theoretical basics of development of a protein interaction blocker that specifically inhibits the interaction between the A20 protein and the Snail1 protein, or the development of a mono ubiquitination inhibitor of Snail1, it will be possible to develop a new cancer suppressor for metastatic breast cancer including triple negative breast cancer in the future”, Professor Park said.
The results of this study were published in the September 11 online edition of Nature Cell Biology (IF Biochemistry, IF: 20.06), the leading professional journal in molecular and cellular biology.